Vancomycin and oxacillin synergy for methicillin-resistant staphylococci.

نویسندگان

  • B E Domaracki
  • A M Evans
  • R A Venezia
چکیده

An increase in oxacillin activity was observed against methicillin-resistant coagulase-negative staphylococci (MRCNS) and methicillin-resistant Staphylococcus aureus (MRSA) in the presence of a sub-MIC of vancomycin. Vancomycin and oxacillin were synergistic against 14 of 21 strains of MRCNS and MRSA. A pattern of enhanced killing was also supported by time-kill studies. These results suggest that combinations of sub-MICs of vancomycin and oxacillin may have therapeutic benefits against methicillin-resistant staphylococci.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 44 5  شماره 

صفحات  -

تاریخ انتشار 2000